Beilstein J. Nanotechnol.2022,13, 699–711, doi:10.3762/bjnano.13.62
viruses.
Keywords: angiotensin converting enzyme-2 (ACE2); antiviralpeptides; hydrogen bonds; molecular docking; SARS-CoV-2 RBD; Introduction
The current pandemic due to coronavirus disease-19 (COVID-19), caused by the novel virus SARS-CoV-2, has over 533 million of confirmed cases and over 6.3 million
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Figure 1:
SARS-CoV-2 bound to the ACE2 receptor. (a) Crystallized complex between the RBD of the SARS-CoV-2 s...
Beilstein J. Nanotechnol.2019,10, 1038–1047, doi:10.3762/bjnano.10.104
demonstrate that conjugation of FluPep to gold and silver nanoparticles enhances its antiviral potency; the antimicrobial activity of silver ions may enable the design of even more potent antimicrobial inhibitors, capable of targeting both influenza and bacterial co-infections.
Keywords: antiviralpeptides
therapeutic use of other antiviralpeptides has been demonstrated in HIV [8][9], hepatitis C [10], herpes simplex [11][12], influenza virus [13][14][15].
The infectivity of influenza A viruses, including the H1N1 subtype, is strongly inhibited by a peptide called FluPep [15]. FluPep was originally identified
biological activity of the peptide, for example, due to multivalent functionalisation of the nanoparticles. In addition, silver possesses innate antimicrobial activities [25]. Thus, noble-metal nanoparticles are potentially useful as both functional probes for antiviralpeptides and as therapeutic delivery
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Figure 1:
Stability of gold nanoparticles to DTT ligand exchange. (A) UV–vis spectra of mixed-matrix-capped g...